Canadian Antimicrobial Resistance Alliance
نویسنده
چکیده
Azoles used for invasive fungal infections include two classes, the imidazoles (ketoconazole) and the triazoles (itraconazole, fluconazole, voriconazole, posaconazole). A number of agents are available for topical use in different indications but this is beyond the paper’s focus. Azoles are usually recognized according to spectrum of activity and safety profiles. The imidazole ring is the synthetic component that confers activity to azoles. Triazoles are obtained by a slight modification of this ring and present similar or improved activity and less adverse effects. Azoles inhibit an enzyme required for the production of ergosterol an essential component of the fungal cytoplasmic membrane. However, since this enzyme is similar to one found in the human liver, drug interactions due to metabolism do occur. Because of important differences in activity and safety it is easier to understand each azole separately.
منابع مشابه
Canadian Antimicrobial Resistance Alliance
Fungi are quite distinct from bacteria in size, cellular structure and chemical composition. These organisms are considered “higher beings” compared with bacteria. They may contain one nucleus or a multiple nuclei surrounded by a specific cell wall. However, their life cycle varies from simple to complex and they may reproduce by both asexual and sexual reproduction. Because of the latter featu...
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